Novel Database for Genetic and Epigenetic Mechanisms in Colon Cancer
by Heather Ruskin, Ana Barat and Ludmila Sarbu
In research on cancer development, alterations in genetic regulatory pathways have attracted more attention than less well-known epigenetic modifications, (eg in DNA methylation, imprinting and chromatin). All are common in cancer, and cause altered gene expression in neoplastic events. Current literature on genetic-epigenetic interactions is largely qualitative and lacks systematic organisation. A novel database is being designed and implemented to provide a way to organise expanding knowledge on genetic-epigenetic interactions, to address key biomedical questions.