by Heather Ruskin, Ana Barat and Ludmila Sarbu
In research on cancer development, alterations in genetic regulatory pathways have attracted more attention than less well-known epigenetic modifications, (eg in DNA methylation, imprinting and chromatin). All are common in cancer, and cause altered gene expression in neoplastic events. Current literature on genetic-epigenetic interactions is largely qualitative and lacks systematic organisation. A novel database is being designed and implemented to provide a way to organise expanding knowledge on genetic-epigenetic interactions, to address key biomedical questions.